Yes it is possible. Just create a ConsoleApp prject and add "WixSharp.bin" NuGet package. That's it.
"WixSharp" package includes "WixSharp.bin" and a custom MSBuild target that triggers building MSI as post C# build step. And it is exactly the step that you don't need.
"WixSharp" package includes "WixSharp.bin" and a custom MSBuild target that triggers building MSI as post C# build step. And it is exactly the step that you don't need.